Symbol
Name
ID

Cox10
heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
MGI:1917633

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Increased CSF lactate	Focal T2 hyperintense thalamic lesion	Ataxia	Reduced eye contact	Agitation	Brisk reflexes	Persistent head lag	Status epilepticus
Disease(s) Associated with COX10
mitochondrial complex IV deficiency nuclear type 3

Mouse Phenotypes

microgliosis

increased microglial cell activation

decreased brain weight

abnormal cingulate gyrus morphology

hippocampal neuron degeneration

abnormal cerebral cortex morphology

abnormal piriform cortex morphology

decreased dopaminergic neuron number

loss of dopaminergic neurons

neuron degeneration

neurodegeneration

abnormal nervous system physiology

abnormal glial cell physiology

Availability

Mouse Genotype

Cox10^tm1Ctm/Cox10^tm1Ctm
Tg(Camk2a-cre)#Szi/0 (conditional)

Cox10^tm1Ctm/Cox10^tm1Ctm
Slc6a3^{tm1.1(cre)Bkmn}/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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